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Crustacean hematopoiesis and the astakine cytokines
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. (Söderhäll)
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. (Söderhäll)
2011 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 117, no 24, 6417-6424 p.Article, review/survey (Refereed) Published
Abstract [en]

Major contributions to research in hematopoiesis in invertebrate animals have come from studies in the fruit fly, Drosophila melanogaster, and the freshwater crayfish, Pacifastacus leniusculus. These animals lack oxygen-carrying erythrocytes and blood cells of the lymphoid lineage, which participate in adaptive immune defence, thus making them suitable model animals to study the regulation of blood cells of the innate immune system. This review presents an overview of crustacean blood cell formation, the role of these cells in innate immunity and how their synthesis is regulated by the astakine cytokines. Astakines are among the first invertebrate cytokines shown to be involved in hematopoiesis, and they can stimulate the proliferation, differentiation and survival of hematopoietic tissue cells. The astakines and their vertebrate homologues, prokineticins, share similar functions in hematopoiesis; thus, studies of astakine-induced hematopoiesis in crustaceans may not only advance our understanding of the regulation of invertebrate hematopoiesis but may also provide new evolutionary perspectives about this process.

Place, publisher, year, edition, pages
2011. Vol. 117, no 24, 6417-6424 p.
National Category
Biological Sciences Hematology
Identifiers
URN: urn:nbn:se:uu:diva-154341DOI: 10.1182/blood-2010-11-320614ISI: 000291684300006PubMedID: 21444913OAI: oai:DiVA.org:uu-154341DiVA: diva2:429851
Available from: 2011-07-06 Created: 2011-05-31 Last updated: 2017-12-11

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