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Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
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2011 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 52, no 7, 1321-1335 p.Article in journal (Refereed) Published
Abstract [en]

Identification of the genomic regions most intimately associated with non-Hodgkin lymphoma (NHL) pathogenesis is confounded by the genetic heterogeneity of human populations. We hypothesize that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. We surveyed non-random aneuploidy in 150 canine NHL cases, revealing limited genomic instability compared to their human counterparts and no evidence for CDKN2A/B deletion in canine B-cell NHL. 'Genomic recoding' of canine NHL data into a 'virtual human' chromosome format showed remarkably few regions of copy number aberration (CNA) shared between both species, restricted to regions of dog chromosomes 13 and 31, and human chromosomes 8 and 21. Our data suggest that gene discovery in NHL may be enhanced through comparative studies exploiting the less complex association between CNAs and tumor pathogenesis in canine patients.

Place, publisher, year, edition, pages
2011. Vol. 52, no 7, 1321-1335 p.
Keyword [en]
Comparative genomic hybridization (CGH), canine, lymphoma, chromosome, microarray
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-156098DOI: 10.3109/10428194.2011.559802ISI: 000291992400024OAI: oai:DiVA.org:uu-156098DiVA: diva2:430595
Available from: 2011-07-11 Created: 2011-07-11 Last updated: 2012-06-12Bibliographically approved

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Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
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