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The evolution of sex-biased genes and sex-biased gene expression
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Evolutionary Biology.
2007 (English)In: Nature reviews genetics, ISSN 1471-0056, Vol. 8, no 9, 689-698 p.Article, review/survey (Refereed) Published
Abstract [en]

Differences between males and females in the optimal phenotype that is favoured by selection can be resolved by the evolution of differential gene expression in the two sexes. Microarray experiments have shown that such sex-biased gene expression is widespread across organisms and genomes. Sex-biased genes show unusually rapid sequence evolution, are often labile in their pattern of expression, and are non-randomly distributed in the genome. Here we discuss the characteristics and expression of sex-biased genes, and the selective forces that shape this previously unappreciated source of phenotypic diversity. Sex-biased gene expression has implications beyond just evolutionary biology, including for medical genetics.

Place, publisher, year, edition, pages
2007. Vol. 8, no 9, 689-698 p.
Keyword [en]
Animals, Chromosome Mapping, Codon/genetics, Evolution; Molecular, Female, Gene Dosage, Gene Expression Regulation, Genes; X-Linked, Genes; Y-Linked, Humans, Male, Open Reading Frames/genetics, Selection (Genetics), Sex Characteristics, Sex Chromosomes/physiology
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-15303DOI: 10.1038/nrg2167ISI: 000248882400015PubMedID: 17680007OAI: oai:DiVA.org:uu-15303DiVA: diva2:43074
Available from: 2008-02-08 Created: 2008-02-08 Last updated: 2011-03-28Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17680007&dopt=Citation

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