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Nocturnal enuresis: theoretic background and practical guidelines
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Pediatrisk inflammationsforskning/Nevéus)
2011 (English)In: Pediatric nephrology (Berlin, West), ISSN 0931-041X, E-ISSN 1432-198X, Vol. 26, no 8, 1207-1214 p.Article, review/survey (Refereed) Published
Abstract [en]

Nocturnal polyuria, nocturnal detrusor overactivity and high arousal thresholds are central in the pathogenesis of enuresis. An underlying mechanism on the brainstem level is probably common to these mechanisms. Enuretic children have an increased risk for psychosocial comorbidity. The primary evaluation of the enuretic child is usually straightforward, with no radiology or invasive procedures required, and can be carried out by any adequately educated nurse or physician. The first-line treatment, once the few cases with underlying disorders, such as diabetes, kidney disease or urogenital malformations, have been ruled out, is the enuresis alarm, which has a definite curative potential but requires much work and motivation. For families not able to comply with the alarm, desmopressin should be the treatment of choice. In therapy-resistant cases, occult constipation needs to be ruled out, and then anticholinergic treatment-often combined with desmopressin-can be tried. In situations when all other treatments have failed, imipramine treatment is warranted, provided the cardiac risks are taken into account.

Place, publisher, year, edition, pages
2011. Vol. 26, no 8, 1207-1214 p.
Keyword [en]
Enuresis, Incontinence, Enuresis alarm, Desmopressin, Anticholinergics, Imipramine
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-156168DOI: 10.1007/s00467-011-1762-8ISI: 000291984200003OAI: oai:DiVA.org:uu-156168DiVA: diva2:430895
Available from: 2011-07-13 Created: 2011-07-13 Last updated: 2014-03-05Bibliographically approved

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Nevéus, Tryggve
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