uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
Show others and affiliations
2011 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 6, no 6, e21344- p.Article in journal (Refereed) Published
Abstract [en]

Both the upper (endocervix and uterus) and lower (ectocervix and vagina) female genital tract mucosa are considered to be target sites for sexual transmission of HIV. There are a few reports on the T cell and antigen-presenting cell distribution in human endometrial tissue however, there is little known about the expression of the HIV co-receptor CCR5 and HIV-binding C-type lectin receptors on endometrial cell subsets. We therefore assessed endometrial tissue sections from HIV seronegative women undergoing hysterectomy of a benign and non-inflammatory cause for phenotypic characterization of potential HIV target cells and receptors by immunohistochemistry. Langerin was expressed on intraepithelial CD1a+CD4+ and CD11c+CD4+ Langerhans cells. Furthermore, CCR5+CD4+CD3+ T cells, DC-SIGN+MR+CD11c+ myeloid dendritic cells and MR+CD68+ macrophages were found within or adjacent to the epithelium of the uterine lumen. In addition, occasional CD123+BDCA-2+ plasmacytoid dendritic cells were detected deep in the endometrial stroma. Both T cells and several antigen-presenting cells were detected in lymphoid aggregate formations in close proximity to the epithelial lining. The finding of intraepithelial and stromal Langerin+ cells as well as CCR5+CD4+ T cells is novel for human endometrium.

Place, publisher, year, edition, pages
2011. Vol. 6, no 6, e21344- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-156222DOI: 10.1371/journal.pone.0021344ISI: 000292290100018OAI: oai:DiVA.org:uu-156222DiVA: diva2:431483
Available from: 2011-07-20 Created: 2011-07-18 Last updated: 2011-07-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Molecular and Morphological Pathology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 180 hits
ReferencesLink to record
Permanent link

Direct link