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Pathogen specific carbohydrate antigen microarrays: a chip for detection of Salmonella O-antigen specific antibodies
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
2008 (English)In: Glycoconjugate Journal, ISSN 0282-0080, E-ISSN 1573-4986, Vol. 25, no 1, 27-36 p.Article in journal (Refereed) Published
Abstract [en]

A Salmonella O-antigen microarray was developed by covalent coupling of oligosaccharide antigens specific for serogroups Salmonella enterica sv. Paratyphi (group A), Typhimurium (group B) and Enteritidis (group D). Antibodies were correctly detected in sera from patients with culture verified salmonellosis. High serogroup-specificity was seen with the disaccharide antigens. With the larger antigens, containing the backbone sequence Man alpha 1-2Rha alpha 1-2Gal (MRG), common backbone-specific antibodies (O-antigen 12) were also detected. This is "proof of principle" that pathogen-specific carbohydrate antigen microarrays constitute a novel technology for rapid and specific serological diagnosis in either individual patients or larger sero-epidemiological and vaccine studies.

Place, publisher, year, edition, pages
Springer , 2008. Vol. 25, no 1, 27-36 p.
Keyword [en]
glycanarray, polysaccharide, oligosaccharide, antibody, salmonellosis
National Category
Organic Chemistry
Research subject
Chemistry with specialization in Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-15420DOI: 10.1007/s10719-007-9045-0ISI: 000252991700006OAI: oai:DiVA.org:uu-15420DiVA: diva2:43191
Available from: 2011-01-05 Created: 2008-02-12 Last updated: 2017-12-08Bibliographically approved

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Norberg, Thomas

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