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Enhanced DNA Sequencing Performance Through Edge-Hydrogenation of Graphene Electrodes
Laboratory of Nano-Fabrication and Novel Devices Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, China.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
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2011 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 21, no 14, 2674-2679 p.Article in journal (Refereed) Published
Abstract [en]

The use of graphene electrodes with hydrogenated edges for solid-state nanopore-based DNA sequencing is proposed, and molecular dynamics simulations in conjunction with electronic transport calculations are performed to explore the potential merits of this idea. The results of the investigation show that, compared to the unhydrogenated system, edge-hydrogenated graphene electrodes facilitate the temporary formation of H-bonds with suitable atomic sites in the translocating DNA molecule. As a consequence, the average conductivity is drastically raised by about 3 orders of magnitude while exhibiting significantly reduced statistical variance. Furthermore, the effect of the distance between opposing electrodes is investigated and two regimes identified: for narrow electrode separation, the mere hindrance due to the presence of protruding hydrogen atoms in the nanopore is deemed more important, while for wider electrode separation, the formation of H-bonds becomes the dominant effect. Based on these findings, it is concluded that hydrogenation of graphene electrode edges represents a promising approach to reduce the translocation speed of DNA through the nanopore and substantially improve the accuracy of the measurement process for whole-genome sequencing.

Place, publisher, year, edition, pages
Weinheim, Germany: WILEY-VCH , 2011. Vol. 21, no 14, 2674-2679 p.
Keyword [en]
whole-genome reading, graphene, nanopore, molecular dynamics simulation, transport calculations
National Category
Nano Technology
Research subject
Physics with spec. in Atomic, Molecular and Condensed Matter Physics
Identifiers
URN: urn:nbn:se:uu:diva-156654DOI: 10.1002/adfm.201002530ISI: 000293715800008OAI: oai:DiVA.org:uu-156654DiVA: diva2:432768
Projects
KoF U3MEC
Funder
Swedish Research Council, 621–2009-3628
Available from: 2011-08-05 Created: 2011-08-05 Last updated: 2017-12-08Bibliographically approved

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Publisher's full texthttp://onlinelibrary.wiley.com/doi/10.1002/adfm.201002530/abstractpreprint

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Scheicher, Ralph H.Grigoriev, AntonAhuja, Rajeev

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