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Antimicrobial susceptibility/resistance and molecular epidemiological characteristics of Neisseria gonorrhoeae in 2009 in Belarus
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2011 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 119, no 8, 537-542 p.Article in journal (Refereed) Published
Abstract [en]

Increased antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global concern, and ultimately gonorrhoea may become untreatable. Nonetheless, AMR data from East-Europe are scarce beyond Russia, and no AMR data or other characteristics of gonococci have been reported from Belarus for more than 20 years. The aim was to describe the prevalence of AMR, and report molecular epidemiological characteristics of gonococci circulating in 2009 in Belarus. In a sample of 80 isolates, resistance prevalences to antimicrobials used for gonorrhoea treatment in Belarus were: Ceftriaxone 0%, spectinomycin 0%, azithromycin 17.3%, tetracycline 25.9%, ciprofloxacin 34.6% and erythromycin 59.2%. The isolates displayed no penA mosaic alleles, 38 porB gene sequences and 35 N. gonorrhoeae multiantigen sequence types, of which 20 have not been described before worldwide. Due to the high levels of antimicrobial resistance, only ceftriaxone and spectinomycin can be recommended for empirical treatment of gonorrhoea in Belarus according to WHO recommendations. Continuous gonococcal AMR surveillance in Eastern Europe is crucial. This is now initiated in Belarus using WHO protocols.

Place, publisher, year, edition, pages
2011. Vol. 119, no 8, 537-542 p.
Keyword [en]
Neisseria gonorrhoeae, antimicrobial resistance, Belarus, Eastern Europe, epidemiology, N. gonorrhoeae multiantigen sequence typing
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-156611DOI: 10.1111/j.1600-0463.2011.02770.xISI: 000292648700007OAI: oai:DiVA.org:uu-156611DiVA: diva2:432804
Available from: 2011-08-07 Created: 2011-08-04 Last updated: 2011-08-07Bibliographically approved

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