Pregnancy and risk of acute myeloid leukaemia: a case-control study
2011 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 87, no 2, 169-171 p.Article in journal (Refereed) Published
Although maternal haematopoiesis is characterised by rapid proliferation and immunological adjustment, leukaemia seldom occurs in pregnant women. In this case-control study, we investigated pregnancy and risk of acute myeloid leukaemia (AML). A total of 785 women with AML diagnosed in ages 15-50 were compared with 1576 age-and sex-matched controls. At the time of diagnosis, 13 cases and 53 controls were pregnant (1.3% and 3.4%, respectively), resulting in a significantly reduced odds ratio of 0.44 (95% confidence interval 0.22-0.85). Odds ratios of AML during the years following childbirth were close to unity. The results suggest that pregnancy conveys a strong short-term protection against AML.
Place, publisher, year, edition, pages
2011. Vol. 87, no 2, 169-171 p.
acute myeloid leukaemia, pregnancy, case-control study, risk factor, maternal
IdentifiersURN: urn:nbn:se:uu:diva-156586DOI: 10.1111/j.1600-0609.2011.01643.xISI: 000292778800009OAI: oai:DiVA.org:uu-156586DiVA: diva2:432832