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Pregnancy and risk of acute myeloid leukaemia: a case-control study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
2011 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 87, no 2, 169-171 p.Article in journal (Refereed) Published
Abstract [en]

Although maternal haematopoiesis is characterised by rapid proliferation and immunological adjustment, leukaemia seldom occurs in pregnant women. In this case-control study, we investigated pregnancy and risk of acute myeloid leukaemia (AML). A total of 785 women with AML diagnosed in ages 15-50 were compared with 1576 age-and sex-matched controls. At the time of diagnosis, 13 cases and 53 controls were pregnant (1.3% and 3.4%, respectively), resulting in a significantly reduced odds ratio of 0.44 (95% confidence interval 0.22-0.85). Odds ratios of AML during the years following childbirth were close to unity. The results suggest that pregnancy conveys a strong short-term protection against AML.

Place, publisher, year, edition, pages
2011. Vol. 87, no 2, 169-171 p.
Keyword [en]
acute myeloid leukaemia, pregnancy, case-control study, risk factor, maternal
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-156586DOI: 10.1111/j.1600-0609.2011.01643.xISI: 000292778800009OAI: oai:DiVA.org:uu-156586DiVA: diva2:432832
Available from: 2011-08-07 Created: 2011-08-04 Last updated: 2017-12-08Bibliographically approved

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Larfors, GunnarHöglund, Martin

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