uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Long-acting hydrocortisone for glucocorticoid replacement therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Show others and affiliations
2007 (English)In: Hormone Research, ISSN 0301-0163, E-ISSN 1423-0046, Vol. 68, no Suppl.5, 182-188 p.Article in journal (Refereed) Published
Abstract [en]

Background: Glucocorticoid (GC) deficiency is a consequence of various disorders that are by themselves rare. Because of this low prevalence, the low cost of GC replacement therapy and the belief that existing outcomes are good, there has been little interest in development of new and improved pharmaceutical products for treatment of GC deficiency. However, GC replacement therapy is complex: diurnal variation of endogenous cortisol must be replicated, GC needs may change during times of physical and psychological stress and there is no biomarker of its action that can be used to monitor individual dose response. Current Limitations: Recent data suggest that the outcome of established long-term GC replacement therapy may not be as good as previously believed. Short-acting GCs such as hydrocortisone (HC) and cortisone acetate for replacement therapy require 2 to 3 administrations per day. Developing Alternatives: Drug delivery system technologies are now available that could permit design and manufacture of a formulation that could accommodate once-daily administration of HC. Such a formulation would enable more physiological serum cortisol-time profiles than are possible with currently available formulations. This short review provides some background on GC replacement therapy, along with recent data on the outcome of patient groups with GC insufficiency, and briefly discusses some general principles for a controlled-release ('long-acting') HC formulation.

Place, publisher, year, edition, pages
2007. Vol. 68, no Suppl.5, 182-188 p.
Keyword [en]
Glucocorticoid, Replacement therapy, Cortisol
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15517DOI: 10.1159/000110621ISI: 000252088400052PubMedID: 18174742OAI: oai:DiVA.org:uu-15517DiVA: diva2:43288
Available from: 2008-02-18 Created: 2008-02-18 Last updated: 2011-03-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18174742&dopt=Citation

Search in DiVA

By author/editor
Lennernäs, Hans
By organisation
Department of Pharmacy
In the same journal
Hormone Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 143 hits
ReferencesLink to record
Permanent link

Direct link