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Adjustable maintenance dosing with budesonide/formoterol (Symbicort) reduces treatment costs in asthma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
2004 (English)In: International journal of clinical practice (Esher), ISSN 1368-5031, E-ISSN 1742-1241, Vol. 58, no s141, 33-41 p.Article in journal (Refereed) Published
Abstract [en]

Adjustable maintenance dosing permits patients to increase or decrease their medication, according to a management plan, in response to daily variations in asthma. Adjustable maintenance dosing with budesonide/formoterol in a single inhaler was compared with fixed dosing bid in eight randomised, open-label studies. Data on resource utilisation were collected prospectively in six of the studies. Duration of randomised treatment was 3 months (UK, Italy, Germany), 4 months (Belgium), 5 months (Canada) or 6 months (Sweden). Mean number of budesonide/formoterol inhalations/day was significantly lower for adjustable maintenance dosing vs. fixed dosing, which resulted in significantly lower drug and total costs with adjustable maintenance dosing vs. fixed-dosing group. In the 3- and 4-month studies, both regimens had similar effectiveness. In the Canadian and Swedish studies, a significantly lower percentage of adjustable maintenance dosing patients had asthma exacerbations compared with fixed dosing. Adjustable maintenance dosing reduced treatment costs, providing similar or better asthma control at a lower overall dose, compared with fixed dosing.

Place, publisher, year, edition, pages
2004. Vol. 58, no s141, 33-41 p.
Keyword [en]
Adjustable maintenance dosing, budesonide, formoterol, Symbicort (R), cost, health economics
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-156850DOI: 10.1111/j.1368-504X.2004.00263.xOAI: oai:DiVA.org:uu-156850DiVA: diva2:433453
Available from: 2011-08-10 Created: 2011-08-10 Last updated: 2011-09-09Bibliographically approved

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Ställberg, Björn
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