Adjustable maintenance dosing with budesonide/formoterol (Symbicort) reduces treatment costs in asthma
2004 (English)In: International journal of clinical practice (Esher), ISSN 1368-5031, E-ISSN 1742-1241, Vol. 58, no s141, 33-41 p.Article in journal (Refereed) Published
Adjustable maintenance dosing permits patients to increase or decrease their medication, according to a management plan, in response to daily variations in asthma. Adjustable maintenance dosing with budesonide/formoterol in a single inhaler was compared with fixed dosing bid in eight randomised, open-label studies. Data on resource utilisation were collected prospectively in six of the studies. Duration of randomised treatment was 3 months (UK, Italy, Germany), 4 months (Belgium), 5 months (Canada) or 6 months (Sweden). Mean number of budesonide/formoterol inhalations/day was significantly lower for adjustable maintenance dosing vs. fixed dosing, which resulted in significantly lower drug and total costs with adjustable maintenance dosing vs. fixed-dosing group. In the 3- and 4-month studies, both regimens had similar effectiveness. In the Canadian and Swedish studies, a significantly lower percentage of adjustable maintenance dosing patients had asthma exacerbations compared with fixed dosing. Adjustable maintenance dosing reduced treatment costs, providing similar or better asthma control at a lower overall dose, compared with fixed dosing.
Place, publisher, year, edition, pages
2004. Vol. 58, no s141, 33-41 p.
Adjustable maintenance dosing, budesonide, formoterol, Symbicort (R), cost, health economics
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-156850DOI: 10.1111/j.1368-504X.2004.00263.xOAI: oai:DiVA.org:uu-156850DiVA: diva2:433453