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Analysis of pharmaceutical powder compaction using multiplicative hyperelasto-plastic theory
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2007 (English)In: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 172, no 2, 103-112 p.Article in journal (Refereed) Published
Abstract [en]

Single-ended compaction of lactose powder is investigated numerically within the framework of multiplicative hyperelasto-plastic theory. In keeping with previous work in the pharmaceutical field, a slightly modified Drucker–Prager Cap model is described and used in the simulations. Coulomb friction is included on all interfaces. Our results indicate that simulations of this type may be useful not only to determine density and stress distributions within tablets, as has been done hitherto, but also may provide indications of circumstances under which the tableting operation fails due to capping.

Place, publisher, year, edition, pages
2007. Vol. 172, no 2, 103-112 p.
Keyword [en]
Powder, Compaction, Pharmaceutical, Continuum model, Multiplicative hyperelasto-plasticity
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-15623DOI: 10.1016/j.powtec.2006.11.001ISI: 000245165000006OAI: oai:DiVA.org:uu-15623DiVA: diva2:43394
Available from: 2008-02-25 Created: 2008-02-25 Last updated: 2017-12-08Bibliographically approved

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Frenning, Göran

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