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Effects of protein-rich supplementation and nandrolone on bone tissue after a hip fracture
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
2007 (English)In: Clinical Nutrition, ISSN 0261-5614, Vol. 26, no 4, 460-465 p.Article in journal (Refereed) Published
Abstract [en]

Background & aims: Osteoporosis is a major health problem worldwide. Low weight is a major risk factor for low bone mass and fractures. The aim of this study was to investigate the effects on bone tissue of protein-rich supplementation alone or in combination with nandrolone decanoate in lean elderly women after a hip fracture. Methods: Sixty elderly women with BMI <24 kg/m2 admitted to hospital due to a femoral neck fracture were randomised to a control group, to receive a protein-rich formula or to receive the same formula with an addition of nandrolone decanoate for 6 months. All patients received additional calcium and vitamin D. The effects after 6 and 12 months were measured by means of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), and with biochemical bone markers. Osteocalcin and C-terminal telopeptide of collagen-1 (CTX) were used to estimate bone formation and bone resorption, respectively. Results: The analyses showed an increase in total body BMD at 6 and 12 months in patients who received protein-rich supplementation. Nandrolone decanoate did not appear to have any additional effect on BMD. Osteocalcin increased in all groups while no significant changes were found for CTX. Conclusion: The overall results of the study indicated that protein-rich supplementation given to lean elderly female hip fracture patients increased the total body BMD.

Place, publisher, year, edition, pages
2007. Vol. 26, no 4, 460-465 p.
Keyword [en]
Absorptiometry; Photon, Aged, Aged; 80 and over, Anabolic Agents/*pharmacology, Biological Markers/analysis, Body Weight/physiology, Bone Density/drug effects, Dietary Proteins/*pharmacology, Dietary Supplements, Female, Fracture Healing/drug effects, Hip Fractures/therapy, Humans, Nandrolone/*pharmacology, Osteocalcin/metabolism, Osteoporosis; Postmenopausal/*drug therapy, Treatment Outcome
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15736DOI: 10.1016/j.clnu.2007.03.007PubMedID: 17498850OAI: oai:DiVA.org:uu-15736DiVA: diva2:43507
Available from: 2008-03-04 Created: 2008-03-04 Last updated: 2010-04-14Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17498850&dopt=Citation

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