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Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
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2007 (English)In: Neuroprotective agents: Eighth international neuroprotection society meeting / [ed] Slikker W; Andrew RJ; Trembly B, 2007, Vol. 1122, no 1, 231-244 p.Conference paper, Published paper (Refereed)
Abstract [en]

Methylene blue (MB), generic name methylthioninium (C16H18ClN3 S · 3H2O), is a blue dye synthesized in 1876 by Heinrich Caro for use as a textile dye and used in the laboratory and clinically since the 1890s, with well-known toxicity and pharmacokinetics. It has experimentally proven neuroprotective and cardioprotective effects in a porcine model of global ischemia–reperfusion in experimental cardiac arrest. This effect has been attributed to MB's blocking effect on nitric oxide synthase and guanylyl cyclase, the latter blocking the synthesis of the second messenger of nitric oxide. The physiological effects during reperfusion include stabilization of the systemic circulation without significantly increased total peripheral resistance, moderately increased cerebral cortical blood flow, a decrease of lipid peroxidation and inflammation, and less anoxic tissue injury in the brain and the heart. The last two effects are recorded as less increase in plasma concentrations of astroglial protein S-100β, as well as troponin I and creatine kinase isoenzyme MB, respectively.

Place, publisher, year, edition, pages
2007. Vol. 1122, no 1, 231-244 p.
Series
Annals of the New York academy of sciences, ISSN 0077-8923 ; 1122
Keyword [en]
cardiac arrest, hemodynamics, methylene blue
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-15742DOI: 10.1196/annals.1403.016ISI: 000252267100016PubMedID: 18077576ISBN: 978-1-57331-685-9 (print)OAI: oai:DiVA.org:uu-15742DiVA: diva2:43513
Conference
8th International Conference on Neuroprotective Agents Mackinac Isl, MI, SEP 18-20, 2006
Available from: 2008-06-02 Created: 2008-06-02 Last updated: 2011-03-24Bibliographically approved

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Wiklund, LarsBasu, SamarMiclescu, AdrianaRonquist, GunnarSharma, Hari Shanker

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Wiklund, LarsBasu, SamarMiclescu, AdrianaRonquist, GunnarSharma, Hari Shanker
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Anaesthesiology and Intensive CareDepartment of Public Health and Caring SciencesDepartment of Surgical SciencesDepartment of Medical Sciences
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