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Expression of interferon-gamma in human adrenal gland and kidney tumours
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2007 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 97, no 3, 420-425 p.Article in journal (Refereed) Published
Abstract [en]

It is known that interferon-γ (IFN-γ) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-γ-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human tumour cells can produce IFN-γ, we examined 429 biopsy specimens of 30 kinds of tumour and tumour-surrounding tissues in adrenal glands and in kidneys by using immunohistochemistry and in situ hybridisation. IFN-γ immunoactivity was shown in 34.3% of the adrenal cortical adenomas, 50% of the adrenal cortical carcinomas, 26.7% of the phaeochromocytomas, 26.7% of the clear cell renal cell carcinomas (RCCs), 22% of the adrenal cortexes and 40% of medullas adjacent to tumours. The positive samples and expression areas were well overlapped between the IFN-γ mRNA and the immunohistochemistry staining. Western blot analysis has further confirmed the immunohistochemistry results by showing a distinct IFN-γ band corresponding to 17.4 kDa in tissue extracts from adrenal cortical adenoma, phaeochromocytoma and clear cell RCCs. These results indicate that IFN-γ is produced by some types of tumour cells, suggesting it may play a dual role in the development of these tumours.

Place, publisher, year, edition, pages
2007. Vol. 97, no 3, 420-425 p.
Keyword [en]
Adrenal tumour, Clear cell renal cell carcinoma, Interferon-γ
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15768DOI: 10.1038/sj.bjc.6603870ISI: 000248444900020PubMedID: 17622250OAI: oai:DiVA.org:uu-15768DiVA: diva2:43539
Available from: 2008-03-05 Created: 2008-03-05 Last updated: 2011-03-25Bibliographically approved

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