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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
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2007 (English)In: Nature, ISSN 0028-0836, Vol. 447, no 7141, 167-177 p.Article in journal (Refereed) Published
Abstract [en]

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.

Place, publisher, year, edition, pages
2007. Vol. 447, no 7141, 167-177 p.
Keyword [en]
Animals, Base Composition, Conserved Sequence/genetics, DNA Transposable Elements/genetics, Evolution; Molecular, Genome/*genetics, Genomics, Humans, Opossums/*genetics, Polymorphism; Single Nucleotide/genetics, Protein Biosynthesis, Synteny/genetics, X Chromosome Inactivation/genetics
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15798DOI: 10.1038/nature05805PubMedID: 17495919OAI: oai:DiVA.org:uu-15798DiVA: diva2:43569
Available from: 2008-03-06 Created: 2008-03-06 Last updated: 2011-08-23Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17495919&dopt=Citation

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Grabherr, ManfredLindblad-Toh, Kerstin
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