uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Initial sequence and comparative analysis of the cat genome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Show others and affiliations
2007 (English)In: Genome Research, ISSN 1088-9051, E-ISSN 1549-5469, Vol. 17, no 11, 1675-1689 p.Article in journal (Refereed) Published
Abstract [en]

The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and short tandem repeats (STRs), suitable for linkage or association studies were characterized in the context of long stretches of chromosome homozygosity. In spite of the light coverage capturing approximately 65% of euchromatin sequence from the cat genome, these comparative insights shed new light on the tempo and mode of gene/genome evolution in mammals, promise several research applications for the cat, and also illustrate that a comparative approach using more deeply covered mammals provides an informative, preliminary annotation of a light (1.9-fold) coverage mammal genome sequence.

Place, publisher, year, edition, pages
2007. Vol. 17, no 11, 1675-1689 p.
Keyword [en]
Animals, Cats/*genetics, Dogs, Genome, Genomics, Humans, Mice, MicroRNAs, Microsatellite Repeats, Models; Genetic, Polymorphism; Single Nucleotide, Rats, Repetitive Sequences; Nucleic Acid
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15824DOI: 10.1101/gr.6380007PubMedID: 17975172OAI: oai:DiVA.org:uu-15824DiVA: diva2:43595
Available from: 2008-03-06 Created: 2008-03-06 Last updated: 2010-04-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17975172&dopt=Citation

Search in DiVA

By author/editor
Lindblad-Toh, Kerstin
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Genome Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 255 hits
ReferencesLink to record
Permanent link

Direct link