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Expression of mast cell tryptases in Hodgkin and Reed-Sternberg (HRS) cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
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2008 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 67, no 1, 53-56 p.Article in journal (Refereed) Published
Abstract [en]

Tryptase is the most abundant protease in human mast cells, and is often used as a marker for the enumeration of mast cells in tissue. Here we report that tumour cells from Hodgkin lymphoma, the so called Hodgkin and Reed-Sternberg cells, can express tryptase. Hodgkin lymphoma cell lines expressed mRNA for both alpha- and beta-tryptase and also produced the protein, although at much lower concentrations than mast cells. However, the frequency of tryptase positive HRS-cells in situ was very low. This report demonstrates that tumour cells of lymphoid origin can express tryptase in vitro and in situ.

Place, publisher, year, edition, pages
2008. Vol. 67, no 1, 53-56 p.
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Clinical Medicine
URN: urn:nbn:se:uu:diva-15829DOI: 10.1111/j.1365-3083.2007.02033.xISI: 000251329700008PubMedID: 18021188OAI: oai:DiVA.org:uu-15829DiVA: diva2:43600
Available from: 2008-03-07 Created: 2008-03-07 Last updated: 2014-10-07Bibliographically approved

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Glimelius, Ingrid
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