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The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (Lymfomgruppen)
(Lymfomgruppen)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (Lymfomgruppen)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (Lymfomgruppen)
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2007 (English)In: Hematology/Oncology Clinics of North America, ISSN 0889-8588, E-ISSN 1558-1977, Vol. 21, no 5, 805-823 p.Article in journal (Refereed) Published
Abstract [en]

The innate immune system is our first line of defense against danger signals but in Hodgkin's lymphoma the role seems opposite, favoring malignant development. In this article we describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the activated immune cells probably promote tumor cell growth and survival along with angiogenesis. Mast cells and eosinophils seem also to contribute to the fibrosis that is so characteristic for nodular sclerosis.

Place, publisher, year, edition, pages
2007. Vol. 21, no 5, 805-823 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-15830DOI: 10.1016/j.hoc.2007.07.007ISI: 000250495500004PubMedID: 17908621OAI: oai:DiVA.org:uu-15830DiVA: diva2:43601
Available from: 2008-03-07 Created: 2008-03-07 Last updated: 2017-12-08Bibliographically approved

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Enblad, GunillaMolin, DanielGlimelius, IngridFischer, Marie

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