Convergent evolution of human and bovine haptoglobin: partial duplication of the genes
2007 (English)In: Journal of Molecular Evolution, ISSN 0022-2844, E-ISSN 1432-1432, Vol. 65, no 4, 373-379 p.Article in journal (Refereed) Published
Haptoglobin (Hp) is a hemoglobin-binding plasma protein consisting of two types of chains, called α and β, which originate from a common polypeptide. In humans, but not in other mammals, Hp has been shown to occur in two allelic forms, Hp1 and Hp2, which differ in the length of the α-chain. The longer α-chain (in Hp2) seems to have arisen by an internal duplication of a gene segment coding for almost the entire α-chain of Hp1. In this article we show that Hp of cow (Bos taurus) contains an α-chain, the structure of which is similar to that of the human Hp2 α-chain. Furthermore, comparison of the structure of bovine Hp and human Hp2 suggests that the bovine gene arose by a duplication of the gene segment homologous to that duplicated in human Hp2. However, a phylogenetic analysis indicates that the two genes were formed independently. The evolutionary pressure that has led to the fixation of the Hps with a longer α-chain is not known.
Place, publisher, year, edition, pages
2007. Vol. 65, no 4, 373-379 p.
Bos Taurus, Convergent evolution, Haptoglobin, Hemoglobin, Human, Partial gene duplication
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-15856DOI: 10.1007/s00239-007-9002-3ISI: 000250626400002PubMedID: 17922076OAI: oai:DiVA.org:uu-15856DiVA: diva2:43627