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Convergent evolution of human and bovine haptoglobin: partial duplication of the genes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2007 (English)In: Journal of Molecular Evolution, ISSN 0022-2844, E-ISSN 1432-1432, Vol. 65, no 4, 373-379 p.Article in journal (Refereed) Published
Abstract [en]

Haptoglobin (Hp) is a hemoglobin-binding plasma protein consisting of two types of chains, called α and β, which originate from a common polypeptide. In humans, but not in other mammals, Hp has been shown to occur in two allelic forms, Hp1 and Hp2, which differ in the length of the α-chain. The longer α-chain (in Hp2) seems to have arisen by an internal duplication of a gene segment coding for almost the entire α-chain of Hp1. In this article we show that Hp of cow (Bos taurus) contains an α-chain, the structure of which is similar to that of the human Hp2 α-chain. Furthermore, comparison of the structure of bovine Hp and human Hp2 suggests that the bovine gene arose by a duplication of the gene segment homologous to that duplicated in human Hp2. However, a phylogenetic analysis indicates that the two genes were formed independently. The evolutionary pressure that has led to the fixation of the Hps with a longer α-chain is not known.

Place, publisher, year, edition, pages
2007. Vol. 65, no 4, 373-379 p.
Keyword [en]
Bos Taurus, Convergent evolution, Haptoglobin, Hemoglobin, Human, Partial gene duplication
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-15856DOI: 10.1007/s00239-007-9002-3ISI: 000250626400002PubMedID: 17922076OAI: oai:DiVA.org:uu-15856DiVA: diva2:43627
Available from: 2008-03-11 Created: 2008-03-11 Last updated: 2017-12-08Bibliographically approved

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Fries, Erik

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