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Genome sequencing and assembly
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2011 (English)In: Methods in molecular biology (Clifton, N.J.), ISSN 1940-6029, Vol. 722, 1-9 p.Article in journal (Refereed) Published
Abstract [en]

Decoding the genome sequence is becoming a fundamental tool for molecular, genetic, and genomic studies. This chapter reviews the history of DNA sequencing and technical principles of different sequencing platforms, and compares the strengths and weaknesses of different techniques for high-throughput genome sequencing applications are compared. It also covers brief descriptions on genome assembly and its validation.

Place, publisher, year, edition, pages
2011. Vol. 722, 1-9 p.
Keyword [en]
Genome sequencing, Genome assembly, Next-generation sequencing, Single-molecule
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-157840DOI: 10.1007/978-1-61779-040-9_1PubMedID: 21590409OAI: oai:DiVA.org:uu-157840DiVA: diva2:436499
Available from: 2011-08-23 Created: 2011-08-23 Last updated: 2012-02-24Bibliographically approved

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Grabherr, Manfred G
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Department of Medical Biochemistry and Microbiology
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