uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
Show others and affiliations
2009 (English)In: Nature, ISSN 1476-4687, Vol. 459, no 7247, 657-62 p.Article in journal (Refereed) Published
Abstract [en]

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.

Place, publisher, year, edition, pages
2009. Vol. 459, no 7247, 657-62 p.
URN: urn:nbn:se:uu:diva-157849DOI: 10.1038/nature08064PubMedID: 19465905OAI: oai:DiVA.org:uu-157849DiVA: diva2:436506
Available from: 2011-08-23 Created: 2011-08-23 Last updated: 2011-08-23

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Grabherr, Manfred

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 290 hits
ReferencesLink to record
Permanent link

Direct link