uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
Show others and affiliations
2005 (English)In: Nature, ISSN 1476-4687, Vol. 438, no 7069, 803-19 p.Article in journal (Refereed) Published
Abstract [en]

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

Place, publisher, year, edition, pages
2005. Vol. 438, no 7069, 803-19 p.
URN: urn:nbn:se:uu:diva-157854DOI: 10.1038/nature04338PubMedID: 16341006OAI: oai:DiVA.org:uu-157854DiVA: diva2:436509
Available from: 2011-08-23 Created: 2011-08-23 Last updated: 2011-08-23

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindblad-Toh, KerstinGrabherr, Manfred

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 370 hits
ReferencesLink to record
Permanent link

Direct link