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Mutation load in sexual and asexual populations: Effects of distributed selection coefficients on stationary fitness and rate of fitness loss
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Molecular Evolution. (Otto Berg)
(English)Manuscript (preprint) (Other academic)
Identifiers
URN: urn:nbn:se:uu:diva-157896OAI: oai:DiVA.org:uu-157896DiVA: diva2:436988
Available from: 2011-08-26 Created: 2011-08-26 Last updated: 2011-11-03
In thesis
1. Surviving the ratchet: Modelling deleterious mutations in asexual populations
Open this publication in new window or tab >>Surviving the ratchet: Modelling deleterious mutations in asexual populations
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely.  With the aid of computational and mathematical models, we have studied other situations where this threat is averted and the organism can survive the ratchet.

The results show that a ratchet where all mutations have the same deleterious fitness effect is very effectively stalled for large effects. However, if mutations are allowed to have a broad range of effects, the fitness-loss rate can be substantial even with the same mean effect as the one-type ratchet, but we have  identified parameter regions where even the broad-range effects are effectively stopped.

The fitness-loss from a ratchet is very sensitive to the mutation rate and a mutation that increases the mutation rate (mutator) can easily start an otherwise stalled ratchet. Large effect mutators are heavily counter-selected, but smaller mutators can spread in the population. They can be stopped by reversals (antimutators), but even if the mutation rate is equilibrated in this way, there will be large fluctuations in mutation rate and even larger in the fitness-loss rate due to the feedback amplification in their coupling.   

Another way of preventing the ratchet is by reversal of the deleterious mutations themselves through back-mutations or compensatory mutations. The rate required to stop the ratchet using only back-mutations before the fitness collapses is very large. A detailed comparison between the deleterious mutations in the ratchet and in a sexual population was made and the difference was found to be greatest for large populations with large genomes.

There are obviously many ways to survive the ratchet, but even more ways to drive a species to extinction by enhancing and speeding up the ratchet. By modelling and testing the ratchet for numerous different situations, we show the effects of some of these threats and benefits.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2011. 38 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 846
Keyword
Theoretical biology, Population genetics, Stochastic modelling, Genome evolution, Muller's Ratchet
National Category
Genetics Microbiology Biological Sciences
Research subject
Biology with specialization in Molecular Evolution
Identifiers
urn:nbn:se:uu:diva-157897 (URN)978-91-554-8137-7 (ISBN)
Public defence
2011-10-07, Ekmansalen, Evolutionsbiologiskt centrum, EBC Norbyvägen 14, Uppsala, 13:00 (English)
Opponent
Supervisors
Available from: 2011-09-15 Created: 2011-08-26 Last updated: 2011-11-03Bibliographically approved

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Söderberg, Jonas

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