Model-based mapping of fat unsaturation and chain length by chemical shift imaging: phantom validation and in vivo feasibility
2012 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 68, no 6, 1815-1827 p.Article in journal (Refereed) Published
Knowledge about the triglyceride (fat) 1H spectrum enables quantitative determination of several triglyceride characteristics. This work describes a model-based chemical shift imaging method that separates water and fat signal and provides maps of three triglyceride quantities: fatty acid carbon chain length (CL), number of double bond pairs (ndb), and number of methylene-interrupted double bonds (nmidb). The method was validated by imaging a phantom containing ten diﬀerent oils using 1.5 T and 3.0 T clinical scanners, with gas-liquid chromatography (GLC) as reference. Repeated acquisitions demonstrated high reproducibility of the method. Statistical tests of correlation and linear regression were performed to examine the accuracy of the method. Signiﬁcant correlation was found at both ﬁeld strengths for all three quantities, and high correlation (r2 > 0.96) was found for measuring ndb and nmidb. Feasibility of the method for in vivo imaging of the thigh was demonstrated at both ﬁeld strengths. The estimates of ndb and nmidb in subcutaneous adipose tisse were in agreement with literature values, while CL appears overestimated. The method has potential use in large-scale cross-sectional and longitudinal studies of triglyceride composition, and its relation to diet and various diseases.
Place, publisher, year, edition, pages
2012. Vol. 68, no 6, 1815-1827 p.
water/fat separation, chemical shift imaging, quantitative MRI, fat unsaturation, triglyceride mapping, fatty acid composition
Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:uu:diva-158098DOI: 10.1002/mrm.24196ISI: 000311398600015PubMedID: 22334300OAI: oai:DiVA.org:uu-158098DiVA: diva2:437953