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White blood cell counts associate more strongly to the metabolic syndrome in 75-year-old women than in men: a population based study.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2007 (English)In: Metabolic Syndrome and Related Disorders, ISSN 1540-4196, E-ISSN 1557-8518, Vol. 5, no 4, 359-364 p.Article in journal (Refereed) Published
Abstract [en]

Background: A positive relation between the metabolic syndrome (MetS) and inflammatoryactivity has been reported. The purpose of this investigation was to study the relationshipsbetween 1) white blood cell (WBC) count and MetS, 2) WBC count and the individual com-ponents of MetS and 3) WBC count and insulin sensitivity in 75-year-old women and menfrom the general population.   Methods: The study included 200 women and 196 men comprising 64% of the 75-year oldpeople from the city of Västerås in Sweden. MetS was defined according to the National Cho-lesterol Education Program (NCEP).   Results: WBC count (109/L; median and interquartile range) was 5.7 (4.9–6.8) for women and6.3 (5.4–7.2) for men, P Ͻ .001 for gender difference. For women with and without MetS, WBCcount was 6.3 (5.3–7.3) and 5.4(4.7–6.3), respectively. For men the corresponding figures were6.7 (5.9–7.6) and 6.1 (5.4–7.1).The difference in WBC count between individuals with and with-out MetS was significant (P Ͻ .001 for women; P ϭ .014 for men). All individual componentsof MetS (with exception of blood pressure) were more strongly associated with WBC countfor women than for men. Insulin sensitivity, measured as HOMA-IR (HOmeostasis ModelAssessment-Insulin Resistance) index, was significantly associated with WBC count in wo-men but not in men.   Conclusions: In this elderly population, individuals with MetS had a higher WBC countthan those without. Women had a lower WBC count and stronger relationship between WBCcount and insulin sensitivity than did men.

Place, publisher, year, edition, pages
2007. Vol. 5, no 4, 359-364 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16034DOI: 10.1089/met.2007.0012PubMedID: 18370806OAI: oai:DiVA.org:uu-16034DiVA: diva2:43805
Available from: 2008-04-08 Created: 2008-04-08 Last updated: 2010-06-09Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18370806&dopt=Citation

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Nilsson, G
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Centre for Clinical Research, County of VästmanlandUCR-Uppsala Clinical Research center
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