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Persistence of antibiotic resistance in bacterial populations
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2011 (English)In: FEMS Microbiology Reviews, ISSN 0168-6445, E-ISSN 1574-6976, Vol. 35, no 5, 901-911 p.Article, review/survey (Refereed) Published
Abstract [en]

Unfortunately for mankind, it is very likely that the antibiotic resistance problem we have generated during the last 60 years due to the extensive use and misuse of antibiotics is here to stay for the foreseeable future. This view is based on theoretical arguments, mathematical modeling, experiments and clinical interventions, suggesting that even if we could reduce antibiotic use, resistant clones would remain persistent and only slowly (if at all) be outcompeted by their susceptible relatives. In this review, we discuss the multitude of mechanisms and processes that are involved in causing the persistence of chromosomal and plasmid-borne resistance determinants and how we might use them to our advantage to increase the likelihood of reversing the problem. Of particular interest is the recent demonstration that a very low antibiotic concentration can be enriching for resistant bacteria and the implication that antibiotic release into the environment could contribute to the selection for resistance.

Place, publisher, year, edition, pages
2011. Vol. 35, no 5, 901-911 p.
Keyword [en]
bacterial fitness, compensatory evolution, selective window, minimal inhibitory concentration (MIC), susceptibility, reversibility
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-158125DOI: 10.1111/j.1574-6976.2011.00289.xISI: 000293345800010PubMedID: 21707669OAI: oai:DiVA.org:uu-158125DiVA: diva2:438066
Available from: 2011-08-31 Created: 2011-08-31 Last updated: 2017-12-08Bibliographically approved

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Andersson, Dan I.Hughes, Diarmaid

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