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Painless drug delivery through microneedle-based transdermal patches featuring active infusion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi. (Nordquist)
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2008 (English)In: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 55, no 3, 1063-1071 p.Article in journal (Refereed) Published
Abstract [en]

This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mul/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.

Place, publisher, year, edition, pages
2008. Vol. 55, no 3, 1063-1071 p.
Keyword [en]
drug delivery, insulin, intradermal, microneedles, transdermal
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16044DOI: 10.1109/TBME.2007.906492ISI: 000253733800023PubMedID: 18334398OAI: oai:DiVA.org:uu-16044DiVA: diva2:43815
Available from: 2008-04-10 Created: 2008-04-10 Last updated: 2011-11-17Bibliographically approved

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