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In vivo amyloid imaging with PET in frontotemporal dementia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)
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2008 (English)In: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, E-ISSN 1619-7089, Vol. 35, no 1, 100-106 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: N-methyl[11C]2-(4'methylaminophenyl)-6-hydroxy-benzothiazole (PIB) is a positron emission tomography (PET) tracer with amyloid binding properties which allows in vivo measurement of cerebral amyloid load in Alzheimer's disease (AD). Frontotemporal dementia (FTD) is a syndrome that can be clinically difficult to distinguish from AD, but in FTD amyloid deposition is not a characteristic pathological finding. PURPOSE: The aim of this study is to investigate PIB retention in FTD. METHODS: Ten patients with the diagnosis of FTD participated. The diagnosis was based on clinical and neuropsychological examination, computed tomography or magnetic resonance imaging scan, and PET with 18 Fluoro-2-deoxy-d-glucose (FDG). The PIB retention, measured in regions of interest, was normalised to a reference region (cerebellum). The results were compared with PIB retention data previously obtained from 17 AD patients with positive PIB retention and eight healthy controls (HC) with negative PIB retention. Statistical analysis was performed with a students t-test with significance level set to 0.00625 after Bonferroni correction. RESULTS: Eight FTD patients showed significantly lower PIB retention compared to AD in frontal (p < 0.0001), parietal (p < 0.0001), temporal (p = 0.0001), and occipital (p = 0.0003) cortices as well as in putamina (p < 0.0001). The PIB uptake in these FTD patients did not differ significantly from the HC in any region. However, two of the 10 FTD patients showed PIB retention similar to AD patients. CONCLUSION: The majority of FTD patients displayed no PIB retention. Thus, PIB could potentially aid in differentiating between FTD and AD.

Place, publisher, year, edition, pages
2008. Vol. 35, no 1, 100-106 p.
Keyword [en]
Frontotemporal dementia, Amyloid, PET, PIB, AD
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16056DOI: 10.1007/s00259-007-0523-1ISI: 000251456800015PubMedID: 17846768OAI: oai:DiVA.org:uu-16056DiVA: diva2:43827
Available from: 2008-04-14 Created: 2008-04-14 Last updated: 2017-12-08Bibliographically approved

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Engler, HenrySantillo, Alexander FrizellLindau, MariaLannfelt, LarsLångström, BengtKilander, Lena

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Engler, HenrySantillo, Alexander FrizellLindau, MariaLannfelt, LarsLångström, BengtKilander, Lena
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Department of Medical SciencesDepartment of Public Health and Caring SciencesDepartment of Biochemistry and Organic Chemistry
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European Journal of Nuclear Medicine and Molecular Imaging
Medical and Health Sciences

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