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Coupling of solid-phase microextraction continuous bed (monolithic) capillaries with capillary zone electrophoresis for direct analysis of drugs in biological fluids.
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2008 (English)In: Electrophoresis, ISSN 0173-0835, Vol. 29, no 8, 1753-1760 p.Article in journal (Refereed) Published
Abstract [en]

Hyperlink robust biocompatible solid-phase microextraction (SPME) devices were prepared using continuous bed (monolithic) restricted-access media (RAM) as the SPME capillary insert The RAM-based SPME approach was able to simultaneously separate proteins from a biological sample, while directly extracting the active components of caffeine, paracetamol and acetylsalicylic acid from the drug NeoCitramonum. The devices were interfaced with a CZE system and fully automated analysis for sample preconcentration, desorption, separation and quantification of analytes was evaluated. Comparative study of in-line coupled SPME-CZE using RAM and RP capillary inserts was carried out. Using an SPME (RAM) insert, the calculated caffeine, paracetamol and acetylsalicylic acid LODs in a bovine plasma sample were 0.3, 0.8 and 1.9 ng/mL, respectively.

Place, publisher, year, edition, pages
2008. Vol. 29, no 8, 1753-1760 p.
Keyword [en]
biological fluids, capillary zone electrophoresis, continuous beds, monoliths, rest ricted-access media
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-16100DOI: 10.1002/elps.200800046ISI: 000255703100022PubMedID: 18383020OAI: oai:DiVA.org:uu-16100DiVA: diva2:43871
Available from: 2008-04-21 Created: 2008-04-21Bibliographically approved

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Westerlund, Douglas
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Department of Medicinal Chemistry
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