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Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2011 (English)In: Neurogenetics, ISSN 1364-6745, E-ISSN 1364-6753, Vol. 12, no 3, 211-221 p.Article in journal (Refereed) Published
Abstract [en]

Long-term divergent selection for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the high- (HWS) and low-weight (LWS) selected lines. At selection age (56 days), the lines differ by more than nine times in body weight. The HWS line chickens are compulsive feeders, whereas in the LWS line, some individuals are anorexic and others have very low appetite. Previous studies have implicated the central nervous system and particularly the hypothalamus in these behavioural differences. Here, we compared the mRNA expression in hypothalamus tissue from chickens on day 4 post-hatch using oligonucleotide arrays and found that the divergent selection had resulted in minor but multiple expression differences. Differentially expressed genes were enriched in processes 'DNA metabolism, repair, induction of apoptosis and metabolism'. Several differentially expressed genes participate in the regulation of neuronal plasticity and development, including apoptosis, or are neurotransmittor receptor subtypes. Less change was seen when comparing hypothalamic neuropeptide mediators of appetite such as the melanocortin receptors. The genomic locations of these differentially expressed genes were then compared to the locations of growth QTLs and to a genome-wide map of chromosomal regions that have been under divergent selection between the lines. The results indicate which differentially expressed hypothalamic genes have responded to the divergent selection and that the results predict that it is more likely to find causative genes among these most differentially expressed genes. Because of such differential gene expression in hypothalamus, the lines may adapt behaviourally different particularly to the post-hatch situation when independent feeding to obtain energy is established.

Place, publisher, year, edition, pages
2011. Vol. 12, no 3, 211-221 p.
Keyword [en]
Anorexia, Body weight, Chicken, Divergent selection, Feeding behaviour, Gene expression, Hypothalamus
National Category
Medical and Health Sciences
Research subject
Developmental Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-158327DOI: 10.1007/s10048-011-0290-9ISI: 000294059600006OAI: oai:DiVA.org:uu-158327DiVA: diva2:439004
Available from: 2011-09-06 Created: 2011-09-06 Last updated: 2017-12-08Bibliographically approved

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Hallböök, Finn

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Department of NeuroscienceDepartment of Immunology, Genetics and PathologyDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabDevelopmental Neuroscience
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