Cardiogenic oscillations in spontaneous breathing airway signal reflect respiratory system mechanics
2011 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, no 8, 980-986 p.Article in journal (Refereed) Published
Background: Heartbeat-related pressure oscillations appear at the airway opening. We investigated whether these cardiogenic oscillations (COS) - extracted from spontaneous breathing signals - reflect the compliance of the respiratory system. Methods: Fifteen volunteers breathed spontaneously at normal or reduced chest wall compliance, i.e. with and without thorax strapping, and at normal or reduced lung compliance, induced by positive end-expiratory pressure (PEEP). COS-related signals were extracted by averaging the flow and pressure curve sections, temporally aligned to the electrocardiogram signal. Results: COS-related airway pressure and flow curves correlated closely for each subject (r(2) =0.97±0.02, P<0.0001). At the unstrapped thorax, the oscillation's amplitudes were 0.07±0.03 cmH(2) O (pressure) and 22±10 ml/s (flow). COS-related pressure amplitudes correlated closely with the ratio of tidal volume divided by pressure amplitude (r(2) =0.88, P<0.001) and furthermore increased with either thorax strapping (P<0.001) or with increasing PEEP (P=0.049). Conclusion: We conclude that COS extracted from the pressure and flow signal reflect the compliance of the respiratory system and could potentially allow estimating respiratory system mechanics during spontaneous breathing.
Place, publisher, year, edition, pages
2011. Vol. 55, no 8, 980-986 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-158404DOI: 10.1111/j.1399-6576.2011.02488.xPubMedID: 21770903OAI: oai:DiVA.org:uu-158404DiVA: diva2:439313