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In situ cross-linkable hyaluronan hydrogel enhances chondrogenesis
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
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2011 (English)In: Journal of tissue engineering and regenerative medicine, ISSN 1932-6254, Vol. 5, no 8, E188-E196 p.Article in journal (Refereed) Published
Abstract [en]

The present work describes the feasibility of a cross-linkable injectable hyaluronan hydrogel for cartilage repair. The hydrogel used is a two-component system based on aldehyde-modified hyaluronan and hydrazide-modified polyvinyl alcohol, which are rapidly cross-linked in situ upon mixing. The in vitro study showed that chondrocytes and mesenchymal cells cultured in the gel form cartilage-like tissue, rich in glycosaminoglycans, collagen type II and aggrecan. In a rabbit animal model the injection of the hydrogel improved the healing of a full-thickness cartilage defect created in the knee as compared to non-treated controls. This rabbit study showed that the regenerated cartilage defects stained more intensely for type II collagen upon treatment with the hydrogel. The hyaluronan-based hydrogel may be used as a delivery vehicle for both growth factors and/or cells for cartilage repair. The in vivo study also indicated that the hydrogel alone has a beneficial effect on cartilage regeneration.

Place, publisher, year, edition, pages
2011. Vol. 5, no 8, E188-E196 p.
Keyword [en]
cartilage, injectable hyaluronan, cross-linked, bone morphogenetic protein-2, rabbit model
National Category
Natural Sciences Polymer Chemistry
Research subject
Chemistry with specialization in Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-158604DOI: 10.1002/term.415ISI: 000294164500005OAI: oai:DiVA.org:uu-158604DiVA: diva2:440207
Available from: 2011-09-12 Created: 2011-09-12 Last updated: 2011-11-29Bibliographically approved

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Hilborn, Jöns

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