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Bronchopulmonary C-fibers modulate the breathing pattern in surfactant-depleted juvenile cats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Perinatal, neonatal och barnkardiologisk forskning/Sedin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Perinatal, neonatal och barnkardiologisk forskning/Sedin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Perinatal, neonatal och barnkardiologisk forskning/Sedin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Perinatal, neonatal och barnkardiologisk forskning/Sedin)
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2008 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 160, no 3, 341-349 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the influence of nonmyelinated C-fibers on the breathing pattern by cooling the vagal nerves to temperatures at which myelinated nerve transmission from pulmonary stretch receptors is blocked (+7 degrees C) and further at which nonmyelinated fiber input is blocked (0 degrees C), in anaesthetized spontaneously breathing juvenile cats with normal (L(N)), surfactant-depleted (L(D)) and surfactant-treated (L(T)) lungs. In L(N), vagal cooling from +7 to 0 degrees C decreased respiratory frequency (f(R); -8%; p < 0.01), and increased tidal volume (V(T); +40%; p < 0.01). In the presence of shallow fast breathing in L(D), f(R) decreased (+38 to +7 degrees C: -26%; p < 0.015 and +7 to 0 degrees C: -24%; p < 0.001) and V(T) increased (+37%; p < 0.049 and +88%; p < 0.016). In L(T), f(R) decreased (+7 to 0 degrees C: -21%; p < 0.001), whereas V(T) remained the same at 0 degrees C (+12%; NS). These findings show for the first time that the activity of bronchopulmonary C-fibers have a prominent role in modulating the breathing pattern in juvenile cats with surfactant-depleted lungs.

Place, publisher, year, edition, pages
2008. Vol. 160, no 3, 341-349 p.
Keyword [en]
Control of breathing, vagal cooling, pulmonary stretch receptors, pulmonary C-fiber, surfactant-depletion
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16250DOI: 10.1016/j.resp.2007.10.017ISI: 000254770600013PubMedID: 18088566OAI: oai:DiVA.org:uu-16250DiVA: diva2:44021
Note
*Rieger-Fackeldey Ester och Sindelar Richard, delar 1:a författare.Available from: 2008-05-14 Created: 2009-04-01 Last updated: 2017-12-08Bibliographically approved

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Rieger-Fackeldey, EstherSindelar, RichardSedin, GunnarJonzon, Anders

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