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The proPO-system: pros and cons for its role in invertebrate immunity
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Comparative Physiology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Comparative Physiology.
2008 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 29, no 6, 263-271 p.Article, review/survey (Refereed) Published
Abstract [en]

Melanisation is an important immune response in many invertebrates. Recent evidence also strongly implies that the melanisation (prophenoloxidase activating) cascade is intimately associated with the appearance of factors stimulating cellular defence by aiding phagocytosis and encapsulation reactions. However, some controversy exists in the field, and at least in flies and mosquitoes, the successful combat of some pathogens does not seem to be dependent on phenoloxidase activity. This may be because of redundancy among separate immune mechanisms, inappropriate testing, species differences or a combination thereof. Recently, by using RNA interference against phenoloxidase or in specific host-pathogen interactions where the pathogen prevents melanin production by the host, convincing data have confirmed the importance of this cascade in invertebrate innate immunity.

Place, publisher, year, edition, pages
2008. Vol. 29, no 6, 263-271 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-16273DOI: 10.1016/j.it.2008.02.009ISI: 000257003000003PubMedID: 18457993OAI: oai:DiVA.org:uu-16273DiVA: diva2:44044
Available from: 2008-05-15 Created: 2008-05-15 Last updated: 2017-12-08

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Cerenius, LageSöderhäll, Kenneth

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