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A Single Dose of Recombinant Activated Factor VII (NovoSeven) Did Not Impair the Function of the Coronary Artery Bypass Grafts: Successful Treatment of Critical Bleeding after Cardiac Surgery in Two Cases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Göran Hedenstierna)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Göran Hedenstierna)
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2007 (English)In: Transfusion Medicine and Hemotherapy, ISSN 1660-3796, E-ISSN 1660-3818, Vol. 34, no 3, 204-207 p.Article in journal (Refereed) Published
Abstract [en]

Bleeding disorders and hemorrhages cause considerable morbidity and mortality in cardiac surgical patients. Possible thromboembolic complications make the use of recombinant activated factor VII (rFVIIa) in the treatment of bleeding after cardiac surgery controversial. Case Reports: We describe 2 patients who experienced intractable bleeding after open heart surgery with the use of cardiopulmonary bypass. Bleeding was successfully treated by a single dose (90 g/kg) of rFVIIa without affecting the patency of the grafts. Conclusion: rFVIIa may provide an opportunity for an effective treatment of serious bleeding episodes both during cardiac surgery and in the postoperative course.

Place, publisher, year, edition, pages
2007. Vol. 34, no 3, 204-207 p.
Keyword [en]
Recombinant activated factor VII, rFVIIa, Hemostasis, Cardiac surgery
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16311DOI: 10.1159/000101768OAI: oai:DiVA.org:uu-16311DiVA: diva2:44082
Available from: 2008-05-16 Created: 2008-05-16 Last updated: 2017-12-08Bibliographically approved

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Schilling, ThomasKozian, Alf

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