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Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
2007 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 140, no 1-2, 65-73 p.Article in journal (Refereed) Published
Abstract [en]

Ghrelin (Ghr) is an appetite stimulating hormone that is produced peripherally, by the stomach, and centrally as well. Previous investigations show that Ghr increases food intake and memory retention in rats, and that extra-hypothalamic structures, such as the hippocampus, participate in these effects. In the present work we analyzed the effect on food intake and memory retention induced by Ghr after serotonin (5-HT) availability modification at the serotoninergic synapses. Animals only treated with a selective serotonin reuptake inhibitor (SSRI), fluoxetine (FLU) 5 mg/kg or clomipramine (CLO) 2.5 and 5 mg/kg, showed a significant reduction in both food intake and memory retention. On the contrary, Ghr administration induces a significant increase in food intake and a dose-dependent increase in short and long term memory retention. When the animals were treated with FLU prior to Ghr injection, the food intake induced, as well as the expression of short and long term memory retention, was decreased. In conclusion, evidence presented in this paper suggests that the effects of Ghr on both feeding and memory retention in extra-hypothalamic structures such as the hippocampus, could depend on the availability of 5-HT.

Place, publisher, year, edition, pages
2007. Vol. 140, no 1-2, 65-73 p.
Keyword [en]
Fluoxetine, Food intake, Ghrelin, Memory retention, Step down test
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16321DOI: 10.1016/j.regpep.2006.11.012ISI: 000245151700011PubMedID: 17189653OAI: oai:DiVA.org:uu-16321DiVA: diva2:44092
Available from: 2008-05-16 Created: 2008-05-16 Last updated: 2011-02-09Bibliographically approved

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