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Alpha-melanocyte stimulating hormone and ghrelin: central interaction in feeding control
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2007 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 28, no 10, 2084-2089 p.Article in journal (Refereed) Published
Abstract [en]

Alpha-melanocyte stimulating hormone (alpha-MSH) and ghrelin play significant yet opposite roles in the regulation of feeding: alpha-MSH inhibits, whereas ghrelin stimulates consumption. The two peptidergic systems may interact in the process of food intake control. A single report published thus far has shown that a synthetic agonist of the melanocortin receptors, MTII, injected in the hypothalamic paraventricular nucleus (PVN) decreases feeding generated by ghrelin. We found that very low doses of alpha-MSH and MTII administered ICV significantly reduced ghrelin-dependent hyperphagia. However, an endogenous molecule, alpha-MSH, infused in the PVN did not exert an inhibitory effect on ghrelin-induced consumption, whereas the effective dose of PVN MTII exceeded that necessary to decrease short-term deprivation-induced feeding. We conclude that it is likely that in feeding regulation alpha-MSH and ghrelin "interact" at the central nervous system level, but the involvement of the PVN in this interaction appears questionable.

Place, publisher, year, edition, pages
2007. Vol. 28, no 10, 2084-2089 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16329DOI: 10.1016/j.peptides.2007.07.017ISI: 000250326100022PubMedID: 17719137OAI: oai:DiVA.org:uu-16329DiVA: diva2:44100
Available from: 2008-05-16 Created: 2008-05-16 Last updated: 2011-01-20Bibliographically approved

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