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Dim light melatonin onset in normal adults and its relationship with sleep timing and diurnal preference
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2012 (English)In: Biological rhythm research, ISSN 0929-1016, E-ISSN 1744-4179, Vol. 43, no 5, 497-503 p.Article in journal (Refereed) Published
Abstract [en]

Dim light melatonin onset (DLMO) is defined as the start of the melatonin production in the evening during dim light conditions and has become a reliable phase marker of the circadian clock. The aim of the study was to investigate DLMO and its association with sleep timing and diurnal preferences in healthy working adults during real-life conditions. Fourteen adults were investigated. A sleep diary was kept during the preceding week, but no fixed sleep–wake schedule was implemented. Diurnal preferences were measured with the Horne–O¨ stberg Morningness–Eveningness Questionnaire. DLMO was defined as the time point when melatonin in saliva exceeded a threshold of 3 ng/L. Results showed that DLMO appeared in the expected time interval but was not significantly associated with sleep timing or diurnal preference. The results illustrate the complexity of monitoring sleep patterns in real-life settings.

Place, publisher, year, edition, pages
2012. Vol. 43, no 5, 497-503 p.
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-158778DOI: 10.1080/09291016.2011.605631ISI: 000308443900004OAI: oai:DiVA.org:uu-158778DiVA: diva2:441065
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Delayed Sleep Phase Disorder: Prevalence, Diagnostic aspects, Associated factors and Treatment concepts
Open this publication in new window or tab >>Delayed Sleep Phase Disorder: Prevalence, Diagnostic aspects, Associated factors and Treatment concepts
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Delayed sleep phase disorder (DSPD) is the most common circadian rhythm sleep disorder. Persons with DSPD have great difficulties falling asleep and waking up at conventional times. To diagnose DSPD this delayed sleep-wake rhythm should cause social impairment and distress for the individual. Evening melatonin and morning bright light are the recommended treatments. The overall aim of this thesis was to evaluate at-home treatment with Light therapy (LT) and the feasibility of adding cognitive behavior therapy (CBT) to LT in DSPD, furthermore prevalence, diagnostic aspects and associated factors were investigated.

Study I included 673 randomly selected individuals aged 16–26 years. The prevalence of DSPD was 4.0%. Unemployment (defined as an absence of educational or work activities) and an elevated level of anxiety were associated with DSPD.

In study II, dim light melatonin onset (DLMO) was measured in healthy adults. Time for DLMO DLMO (Mean±SD) was 20:58±55 minutes.

Studies III, IV, and V present results from a randomized controlled trial examining the feasibility of CBT as an additive treatment to LT with scheduled rise times, in persons with DSPD. Sleep onset and sleep offset was significantly advanced from baseline (03:00±1:20; 10:22±2:02 respectively) to the end of LT (01:27±1:41; 08:05±1:29, p<0.001 respectively). This advancement was predicted by consistent daily usage of the LT-lamp. At the follow-ups after LT and CBT or LT alone, sleep onset remained stable, sleep offset was delayed, and sleep difficulties were further improved, but there was no significant group interaction over time. There was a significant group interaction over time in the severity of anxiety and depressive symptoms, both in favor of the LT+CBT group.

Conclusively, DSPD was common among adolescents and young adults and it was associated with unemployment and elevated levels of anxiety. DLMO appeared in the expected time range in healthy working adults. At-home treatment with LT with scheduled rise times advanced sleep-wake rhythm and improved sleep difficulties in DSPD. Even though sleep-wake rhythm was not further advanced or better preserved in the participants that received LT+CBT compared to LT alone, the addition of CBT to the treatment regimen was feasible and well accepted.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 70 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1243
Keyword
delayed sleep phase disorder, prevalence, diagnostic aspects, associated factors, light therapy and cognitive behavior therapy
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-299887 (URN)978-91-554-9645-6 (ISBN)
External cooperation:
Public defence
2016-09-29, Gunnesalen, Akademiska sjukhuset ingång 10, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Available from: 2016-09-07 Created: 2016-07-29 Last updated: 2016-09-13

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Danielsson, KatarinaMarkström, AgnetaStridsberg, MatsBroman, Jan-Erik

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