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Intraventricular ghrelin activates oxytocin neurons: implications in feeding behavior
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2007 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 18, no 5, 499-503 p.Article in journal (Refereed) Published
Abstract [en]

Ghrelin affects behavioral and physiological responses, such as feeding or the activity of the HPA axis. Distribution of its receptor in central sites involved in neuroendocrine control, including the hypothalamic paraventricular nucleus, indicates that interplay with multiple neuropeptidergic systems underlies ghrelin's actions. We report that intracerebroventricular ghrelin increases c-Fos immunoreactivity of oxytocin neurons in magno and parvocellular portions of the paraventricular nucleus. The orexigenic response to ghrelin administered at the dose that activates oxytocin neurons can be further elevated by pretreatment with a selective oxytocin receptor antagonist. Our data suggest that oxytocin may be responsible for the mediation of some effects induced by ghrelin. Modifications in the activity of the oxytocin system may alter some of these effects.

Place, publisher, year, edition, pages
2007. Vol. 18, no 5, 499-503 p.
Keyword [en]
Animals, Behavior; Animal/drug effects, Dose-Response Relationship; Drug, Feeding Behavior/*drug effects, Ghrelin, Injections; Intraventricular/methods, Male, Neurons/*drug effects/*metabolism, Oxytocin/analogs & derivatives/antagonists & inhibitors/*metabolism/pharmacology, Paraventricular Hypothalamic Nucleus/cytology, Peptide Hormones/*pharmacology, Proto-Oncogene Proteins c-fos/metabolism, Rats, Rats; Sprague-Dawley, Time Factors
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16372DOI: 10.1097/WNR.0b013e328058684ePubMedID: 17496811OAI: oai:DiVA.org:uu-16372DiVA: diva2:44143
Available from: 2008-05-20 Created: 2008-05-20 Last updated: 2010-04-23Bibliographically approved

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