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Genetic origin of the Swedish Sami inferred from HLA class I and class II allele frequencies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2008 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 16, no 11, 1341-1349 p.Article in journal (Refereed) Published
Abstract [en]

Sami of northern Scandinavia are genetic outliers among European populations and their origin has been difficult to determine. In order to study the genetic origin of the Swedish Sami, we have performed high-resolution typing of the class I HLA-A and -B loci and the class II DRB1, DQB1 and DQA1 loci in the northern and southern Swedish Sami. Several of the common class I alleles in Sami (B*0702, B*1501, B*4002 and A*0301) are found at high frequency in other European populations. However, a number of class I and class II alleles (B*4001, A*2402, DRB1*0901 and DRB1*1101) in the Swedish Sami are characteristic of Asian populations. Admixture analyses indicate that 87% of the Sami gene pool is of European origin and that the Asian contribution is 13%. Our HLA analyses indicate a higher proportion of Asian ancestry in the Sami than shown by previous genetic studies.

Place, publisher, year, edition, pages
2008. Vol. 16, no 11, 1341-1349 p.
Keyword [en]
Sami, HLA, genetic origin, admixture
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16416DOI: 10.1038/ejhg.2008.88ISI: 000260263500007PubMedID: 18478041OAI: oai:DiVA.org:uu-16416DiVA: diva2:44187
Available from: 2008-05-22 Created: 2008-05-22 Last updated: 2017-12-08Bibliographically approved

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Johansson, ÅsaIngman, MaxGyllensten, Ulf

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