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Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
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2011 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 21, no 5, 261-264 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to investigate the effects of the 5-HTTLPR and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on self-reported Big Five personality traits and their facets in a population representative sample of adolescents. The sample consisted of both cohorts of the Estonian Children Personality Behaviour and Health Study, and personality data were collected during its second waves. The 5-HTTLPR and BDNF Val66Met polymorphisms were genotyped. The BDNF Val66Met had a significant effect on conscientiousness [F(1,807) = 4.32, P = 0.038]. We did not find effects of the 5-HTTLPR polymorphism on the main domains of personality, however, a gene x gene interaction on conscientiousness emerged -BDNF Val66Met Met-allele carriers with the 5-HTTLPR s/s genotype had by far the lowest scores in conscientiousness [F(2,803) = 4.38, P = 0.012]. In addition, we found genotype effects on some facet scales. In conclusion, the BDNF Val66Met genotype Met-allele carriers have lower conscientiousness, and this effect is increased in the 5-HTTLPR s/s individuals.

Place, publisher, year, edition, pages
2011. Vol. 21, no 5, 261-264 p.
Keyword [en]
5-HTTLPR, BDNF Val66Met, five-factor model, gene x gene interaction, personality
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-158857DOI: 10.1097/YPG.0b013e32834371e8ISI: 000294454100007OAI: oai:DiVA.org:uu-158857DiVA: diva2:442254
Available from: 2011-09-20 Created: 2011-09-19 Last updated: 2011-09-20Bibliographically approved

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