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Associations between ten biological tumor markers in squamous cell cervical cancer and serum estradiol, serum progesterone and smoking
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. (Obstetrisk forskning/Axelsson)
2007 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 27, no 3B, 1401-1406 p.Article in journal (Refereed) Published
Abstract [en]

Background and Aim: To study possible associations between selected tumor markers and co-factors in squamous cell cervical cancer. Materials and Methods: Ten biological tumor markers representing different functions in carcinogenesis were diagnosed in 128 cases of squamous cell cervical cancer. These were p53, c-myc, EGFR, COX-2, CD4+, VEGF, E-cadherin, CD44, Ki-67 (MIB-1), and p27. Smoking habits and previous oral contraceptive use were registered. Serum estradiol and progesterone levels were evaluated in 80 women. Each marker was compared to these four variables. Results: Highly significant associaions were found between strong c-myc staining (≥50%) and increased serum progesterone (p=0.01), a low EGFR staining (<20%) and high serum estradiol (p=0.0007), and an absence of p53 staining and smoking (p=0.008). There was a association between the absence of p53 and high serum progesterone (p=0.046). Conclusion: The study supports a role of progesterone as a promoter of cervical cancer and indicates that smoking is associated with tumor development.

Place, publisher, year, edition, pages
2007. Vol. 27, no 3B, 1401-1406 p.
Keyword [en]
c-myc, Cervical cancer, Epithelial growth factor receptor, Estradiol, p53, Progesterone, Smoking
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16502ISI: 000246650700003PubMedID: 17595754OAI: oai:DiVA.org:uu-16502DiVA: diva2:44273
Available from: 2008-05-27 Created: 2008-05-27 Last updated: 2017-12-08Bibliographically approved

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