Associations between ten biological tumor markers in squamous cell cervical cancer and serum estradiol, serum progesterone and smoking
2007 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 27, no 3B, 1401-1406 p.Article in journal (Refereed) Published
Background and Aim: To study possible associations between selected tumor markers and co-factors in squamous cell cervical cancer. Materials and Methods: Ten biological tumor markers representing different functions in carcinogenesis were diagnosed in 128 cases of squamous cell cervical cancer. These were p53, c-myc, EGFR, COX-2, CD4+, VEGF, E-cadherin, CD44, Ki-67 (MIB-1), and p27. Smoking habits and previous oral contraceptive use were registered. Serum estradiol and progesterone levels were evaluated in 80 women. Each marker was compared to these four variables. Results: Highly significant associaions were found between strong c-myc staining (≥50%) and increased serum progesterone (p=0.01), a low EGFR staining (<20%) and high serum estradiol (p=0.0007), and an absence of p53 staining and smoking (p=0.008). There was a association between the absence of p53 and high serum progesterone (p=0.046). Conclusion: The study supports a role of progesterone as a promoter of cervical cancer and indicates that smoking is associated with tumor development.
Place, publisher, year, edition, pages
2007. Vol. 27, no 3B, 1401-1406 p.
c-myc, Cervical cancer, Epithelial growth factor receptor, Estradiol, p53, Progesterone, Smoking
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-16502ISI: 000246650700003PubMedID: 17595754OAI: oai:DiVA.org:uu-16502DiVA: diva2:44273