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An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
2011 (English)In: Canadian Journal of Urology, ISSN 1195-9479, Vol. 18, no 4, 5778-5786 p.Article, review/survey (Refereed) Published
Abstract [en]

Photodynamic therapy (PDT) is one of the most interesting methods of photo treatment. In general, PDT is a modality for the treatment of non-muscle invasive tumors. PDT is very well suited in managing bladder cancer, as the bladder is accessible by endoscopy and the tumors are most often limited to the mucosa or sub-mucosa. PDT is likely more useful for patients with recurrent tumors after conventional therapies, as well as for patients with diffuse non-muscle invasive bladder carcinomas that are refractory to standard treatments before the commitment to radical extirpative surgery, particularly in patients at surgical high risk. The treatment of tumors with PDT includes three major parameters: presence of oxygen in tumor tissue, administration of a photosensitizer, and subsequent exposure to light. The PDT mechanism relies on the in situ generation of cytotoxic agents by the activation of a light-sensitive drug, resulting in cell death. In this review, we present past and current advances in the use of PDT with urinary bladder cancer and discuss the future roles for this type of therapy in the treatment of bladder cancer.

Place, publisher, year, edition, pages
2011. Vol. 18, no 4, 5778-5786 p.
Keyword [en]
bladder cancer, photodynamic therapy, photodynamic diagnosis
National Category
Urology and Nephrology Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-159156ISI: 000294528100003PubMedID: 21854709OAI: oai:DiVA.org:uu-159156DiVA: diva2:442881
Available from: 2011-09-22 Created: 2011-09-22 Last updated: 2014-08-15Bibliographically approved

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PubMedhttp://www.canjurol.com/abstract.php?ArticleID=2271&PMID=21854709&version=1.0

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Segersten, UlrikaMalmström, Per-Uno

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