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Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2008 (English)In: Molecular and Cellular Biology, ISSN 0270-7306, E-ISSN 1098-5549, Vol. 28, no 11, 3713-3728 p.Article in journal (Refereed) Published
Abstract [en]

The Kcnq1ot1 antisense noncoding RNA has been implicated in long-range bidirectional silencing, but the underlying mechanisms remain enigmatic. Here we characterize a domain at the 5' end of the Kcnq1ot1 RNA that carries out transcriptional silencing of linked genes using an episomal vector system. The bidirectional silencing property of Kcnq1ot1 maps to a highly conserved repeat motif within the silencing domain, which directs transcriptional silencing by interaction with chromatin, resulting in histone H3 lysine 9 trimethylation. Intriguingly, the silencing domain is also required to target the episomal vector to the perinucleolar compartment during mid-S phase. Collectively, our data unfold a novel mechanism by which an antisense RNA mediates transcriptional gene silencing of chromosomal domains by targeting them to distinct nuclear compartments known to be rich in heterochromatic machinery.

Place, publisher, year, edition, pages
2008. Vol. 28, no 11, 3713-3728 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16556DOI: 10.1128/MCB.02263-07ISI: 000256044000013PubMedID: 18299392OAI: oai:DiVA.org:uu-16556DiVA: diva2:44327
Available from: 2008-05-28 Created: 2008-05-28 Last updated: 2017-12-08Bibliographically approved

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Mohammad, FaizaanPandey, Radha RamanMondal, TanmoyKanduri, Chandrasekhar

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Mohammad, FaizaanPandey, Radha RamanMondal, TanmoyKanduri, Chandrasekhar
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