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Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
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2008 (English)In: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 28, no 5, 975-982 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Signaling events after activation of toll-like receptors (TLRs) are important mechanisms promoting inflammation in the atherosclerotic plaque. INF regulatory factor 5 (IRF5) is one of the mediators of downstream effects of TLRs. Several single nucleotide polymorphisms (SNPs) in the IRF5 gene have been found to be associated with systemic lupus erythematosus.

METHODS AND RESULTS:

We examined IRF5 mRNA expression in carotid atherosclerotic tissue (n=99) and the case-control association between SNPs in the IRF5 gene with myocardial infarction (MI) (n=376+387) and unstable coronary artery disease (CAD) (n=3101+445). Among unstable CAD patients, association of IRF5 SNPs with recurrent coronary events (n=401) was also investigated. The IRF5 mRNA expression was increased in atherosclerotic tissue compared with control tissue (P<0.001). Significant associations with IRF5 expression was observed for 6 of 10 SNPs in the study. However, the IRF5 SNPs examined were neither associated with the risk of precocious MI, nor with unstable CAD or risk of recurrent cardiovascular events in unstable CAD patients.

CONCLUSIONS:

IRF5 mRNA is expressed in cells in atherosclerotic tissue and its expression is modified by SNPs in the IRF5 gene. Genetic variation at the IRF5 locus was, however, not associated with CAD or related phenotypes.

Place, publisher, year, edition, pages
2008. Vol. 28, no 5, 975-982 p.
Keyword [en]
acute coronary syndromes, pathophysiology, gene regulation, genetics of cardiovascular disease, arterial thrombosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16559DOI: 10.1161/ATVBAHA.108.163733ISI: 000255056700031PubMedID: 18323517OAI: oai:DiVA.org:uu-16559DiVA: diva2:44330
Available from: 2008-05-28 Created: 2008-05-28 Last updated: 2017-12-08Bibliographically approved

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Wallentin, LarsSiegbahn, AgnetaSyvänen, Ann-Christine

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