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Substance P N-terminal fragment SP(1-7) attenuates chronic morphine tolerance and affects dynorphin B and nociceptin in rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Biologisk beroendeforskning)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Biologisk beroendeforskning)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Biologisk beroendeforskning)
2011 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 32, no 8, 1661-1665 p.Article in journal (Refereed) Published
Abstract [en]

The N-terminal substance P fragment SP(1-7) is known to modulate hyperalgesia and opioid withdrawal in animal models. This study examined the effects of intraperitoneal (i.p.) injections of SP(1-7) on chronic morphine tolerance and on the levels of dynorphin B (DYN B) and nociceptin/orphanin FQ(N/OFQ) in various brain areas of male Sprague Dawley rats. Morphine tolerance was induced by subcutaneous injections of the opioid (10 mg/kg) twice daily for 7 days. SP(1-7) injected i.p. (185 nmol/kg) 30 min prior to morphine reduced the development of morphine tolerance. Immunoreactive (it) DYN B and N/OFQ peptide levels were measured in several areas of the central nervous system. Levels of ir DYN B in rats treated with SP(1-7) and morphine were decreased in the nucleus accumbens. substantia nigra and ventral tegmental area and increased in the frontal cortex. The ir N/OFQ levels were increased in the periaqueductal gray and decreased in the nucleus accumbens. Since the concentration profiles of the two peptides were altered by SP(1-7) in the areas that are implicated in the modulation of opioid tolerance and analgesia, it is suggested that DYN B and N/OFQ systems may be involved in the effects of SP(1-7) on opioid tolerance.

Place, publisher, year, edition, pages
2011. Vol. 32, no 8, 1661-1665 p.
Keyword [en]
Dynorphin B (DYN B), Morphine, Nociceptin/orphanin FQ (N/OFQ), Opioid tolerance, Rat brain, Substance P (SP), SP(1-7)
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-159258DOI: 10.1016/j.peptides.2011.06.030ISI: 000294572800014OAI: oai:DiVA.org:uu-159258DiVA: diva2:443524
Available from: 2011-09-26 Created: 2011-09-26 Last updated: 2017-12-08Bibliographically approved

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Zhou, QinHallberg, MathiasNyberg, Fred

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