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Physiologic responses and plasma endothelin-1 concentrations associated with abrupt cessation of nitric oxide inhalation in isoflurane-anesthetized horses
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
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2008 (English)In: American Journal of Veterinary Research, ISSN 0002-9645, E-ISSN 1943-5681, Vol. 69, no 3, 423-430 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess physiologic responses and plasma endothelin (ET)-1 concentrations associated with abrupt cessation of nitric oxide (NO) inhalation in isoflurane-anesthetized horses. ANIMALS: 6 healthy adult Standardbreds. PROCEDURES: Horses were anesthetized with isoflurane in oxygen and placed in dorsal recumbency. Nitric oxide was pulsed into the respiratory tract for 2.5 hours, and then administration was abruptly discontinued. Just prior to commencement and at cessation of NO administration, and at intervals during a 30-minute period following cessation of NO inhalation, several variables including PaO(2), mean pulmonary artery pressure, venous admixture or pulmonary shunt fraction (Qs/Qt), and plasma ET-1 concentration were recorded or calculated. RESULTS: After cessation of NO inhalation, PaO(2) decreased slowly but significantly (172.7 +/- 29.8 mm Hg to 84.6 +/- 10.9 mm Hg) and Qs/Qt increased slowly but significantly (25 +/- 2% to 40 +/- 3%) over a 30-minute period. Mean pulmonary artery pressure increased slightly (14.0 +/- 1.3 mm Hg to 16.8 +/- 1 mm Hg) over the same time period. No change in serum ET-1 concentration was detected, and other variables did not change or underwent minor changes. CONCLUSIONS AND CLINICAL RELEVANCE: The improvement in arterial oxygenation during pulsed inhalation of NO to healthy isoflurane-anesthetized horses decreased only gradually during a 30-minute period following cessation of NO inhalation, and serum ET-1 concentration was not affected. Because a rapid rebound response did not develop, inhalation of NO might be clinically useful in the treatment of hypoxemia in healthy isoflurane-anesthetized horses.

Place, publisher, year, edition, pages
2008. Vol. 69, no 3, 423-430 p.
Keyword [en]
Administration; Inhalation, Anesthesia; Inhalation/*veterinary, Animals, Blood Gas Analysis/veterinary, Blood Pressure/drug effects, Bronchodilator Agents/*administration & dosage, Endothelin-1/*blood, Female, Heart Rate/drug effects, Horses/blood/*physiology, Male, Nitric Oxide/*administration & dosage, Respiration/drug effects
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16601DOI: 10.2460/ajvr.69.3.423ISI: 000254067300015PubMedID: 18312143OAI: oai:DiVA.org:uu-16601DiVA: diva2:44372
Available from: 2008-05-29 Created: 2008-05-29 Last updated: 2017-12-08Bibliographically approved

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Högman, Marieann

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