Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase
2007 (English)In: Combinatorial chemistry & high throughput screening, ISSN 1386-2073, Vol. 10, no 9, 783-789 p.Article in journal (Refereed) Published
A microwave-enhanced, palladium-catalyzed protocol for the alpha-arylation of a protected glycine in neat water is described. This reaction proceeds rapidly, under non-inert conditions, to afford a range of phenylglycine derivatives in moderate to good yields. Based on this arylation, a number of aryl L-methionine-SR-sulfoximine (MSO) analogues were prepared and evaluated for their Mycobacterium tuberculosis glutamine synthetase (TB-GS) inhibitory activity.
Place, publisher, year, edition, pages
2007. Vol. 10, no 9, 783-789 p.
arylation, glutamine synthetase, microwave, palladium, tuberculosis, water
IdentifiersURN: urn:nbn:se:uu:diva-16614DOI: 10.2174/138620707783018478ISI: 000253584600005PubMedID: 18478959OAI: oai:DiVA.org:uu-16614DiVA: diva2:44385