uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
Show others and affiliations
2007 (English)In: Journal of Agricultural and Food Chemistry, ISSN 0021-8561, E-ISSN 1520-5118, Vol. 55, no 23, 9365-9372 p.Article in journal (Refereed) Published
Abstract [en]

Antifeedant activity of mainly phenylpropanoic, cinnamic, and benzoic acids esters was tested on the pine weevil, Hylobius abietis (L.). Of 105 compounds screened for activity, 9 phenylpropanoates, 3 cinnamates, and 4 benzoates were found to be highly active antifeedants. To understand the structure–activity relationships of these compounds, a multivariate analysis study was performed. A number of molecular and substituent descriptors were calculated and correlated to results from two-choice feeding tests with H. abietis. Three local models were developed that had good internal predictive ability. External test sets showed moderate predictivity. In general, low polarity, small size, and high lipophilicity were characteristics for compounds having good antifeedant activity.

Place, publisher, year, edition, pages
2007. Vol. 55, no 23, 9365-9372 p.
Keyword [en]
Benzoates, Cinnamates, Conifer seedling, Curculionidae, Feeding deterrent, Hylobius abietis, Large pine weevil, Multivariate analysis, Phenylacrylates, Phenylpropanoates, Phenylpropenoates, PLS, QSAR
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-16620DOI: 10.1021/jf070014pISI: 000250794100007PubMedID: 17927202OAI: oai:DiVA.org:uu-16620DiVA: diva2:44391
Available from: 2008-05-29 Created: 2008-05-29 Last updated: 2011-03-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nordqvist, AnneliKarlén, Anders
By organisation
Department of ChemistryDepartment of Medicinal Chemistry
In the same journal
Journal of Agricultural and Food Chemistry
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 121 hits
ReferencesLink to record
Permanent link

Direct link